A novel cystic fibrosis-mimetic Pseudomonas auxotrophic vaccine is protective in vivo and is associated with IL-17/IgA mucosal Immunity
Youssouf Sereme, Bérengère Villeret, Ségolène Caboche, Samuel Ikeh, Hugo Leroy, Delphine Beury, Florence Maurier, Christophe Desterke, Maëlys Born-Bony, Zhou Xing, Romé Voulhoux, Jean-Michel Sallenave · 2026
Read A novel cystic fibrosis-mimetic Pseudomonas auxotrophic vaccine is protective in vivo and is associated with IL-17/IgA mucosal Immunity by Youssouf Sereme, Bérengère Villeret, Ségolène Caboche, Samuel Ikeh, Hugo Leroy, Delphine Beury, Florence Maurier, Christophe Desterke, Maëlys Born-Bony, Zhou Xing, Romé Voulhoux, Jean-Michel Sallenave (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13555540.txt.
Description
Youssouf Sereme leads a twelve-author team building a live vaccine strain against Pseudomonas, a germ that haunts cystic fibrosis lungs, in a 2026 study. No vaccine exists for this germ despite its danger to vulnerable patients. The team grew a weakened strain in fake sputum mimicking diseased lung mucus. The strain adapted, needing outside nutrients to grow, a safety trait called auxotrophy.
The adapted strain looked and behaved like germs found in chronic lung infections, yet caused less harm. Given into mouse lungs, it sparked local and body-wide antibody defences plus memory immune cells. Lung delivery protected mice against a lethal dose of the wild germ, while a muscle shot did not. Mucosal immunity, the authors argue, is the key.
Catalog record
| CREATOR | Youssouf Sereme, Bérengère Villeret, Ségolène Caboche, Samuel Ikeh, Hugo Leroy, Delphine Beury, Florence Maurier, Christophe Desterke, Maëlys Born-Bony, Zhou Xing, Romé Voulhoux, Jean-Michel Sallenave |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65382 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |