Matrine Alleviates Sepsis-Induced Acute Lung Injury by Reinforcing NQO1/SLC7A11/GPX4-Associated Anti-Ferroptotic Defenses and Attenuating NF-κB-Driven Inflammation
Xue Chen, Min Yuan, Ting Huang, Yuxuan Wang, Zihan Lei, Jingxue Qing, Hailong Gong, Delida Aidebaike, Zhengyu Zhang, Xiaojing Wu · 2026
Read Matrine Alleviates Sepsis-Induced Acute Lung Injury by Reinforcing NQO1/SLC7A11/GPX4-Associated Anti-Ferroptotic Defenses and Attenuating NF-κB-Driven Inflammation by Xue Chen, Min Yuan, Ting Huang, Yuxuan Wang, Zihan Lei, Jingxue Qing, Hailong Gong, Delida Aidebaike, Zhengyu Zhang, Xiaojing Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13555525.txt.
Description
Xue Chen and colleagues test a plant alkaloid against sepsis lung damage through iron-death defences. Their study from twenty twenty-six uses a surgical sepsis model. Sepsis inflames the lungs early and severely in many patients. A cell death route driven by iron and fat oxidation contributes.
Matrine comes from a traditional medicinal plant root. Treated animals faced gut-puncture sepsis induction. The drug strengthened a three-protein defence axis in lung tissue. That axis blocks the iron-driven death pathway. It also calmed the main inflammatory signalling route. Lung injury scores reflected the combined protection. Dual action on death and inflammation is the appeal. Further work must test timing and dosing windows.
Catalog record
| CREATOR | Xue Chen, Min Yuan, Ting Huang, Yuxuan Wang, Zihan Lei, Jingxue Qing, Hailong Gong, Delida Aidebaike, Zhengyu Zhang, Xiaojing Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 110 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |