Claudin‐3 Deficiency Potentially Permits Epidermal Nerve Infiltration and Contributes to Sensitive Skin Pathophysiology
Arisa Kato, Akane Kawamoto, Daiki Murase, Hiroyuki Yoshida, Kenji Kabashima · 2026
Read Claudin‐3 Deficiency Potentially Permits Epidermal Nerve Infiltration and Contributes to Sensitive Skin Pathophysiology by Arisa Kato, Akane Kawamoto, Daiki Murase, Hiroyuki Yoshida, Kenji Kabashima (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13555158.txt.
Description
Arisa Kato leads a five-author team probing why sensitive skin stings, looking at nerve endings and a sealing protein in a 2026 study. Sensitive skin reacts with itching, burning, or stinging to mild triggers. In healthy skin, tight junctions in the upper skin layer shield nerve endings from outside irritants. One junction protein, claudin-3, drew the team's focus.
Skin samples came from people classed as sensitive or not by survey and a lactic acid sting test. Sensitive skin lost more water through its surface, hinting at a subtly weaker barrier. Nerve fibres in sensitive samples reached higher, pushing up through zones marked by a sister junction protein. The authors link missing claudin-3 to this nerve exposure, offering a physical basis for the condition.
Catalog record
| CREATOR | Arisa Kato, Akane Kawamoto, Daiki Murase, Hiroyuki Yoshida, Kenji Kabashima |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 8 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |