Shared genetic architecture between DTI‐ALPS traits and neurodegenerative diseases
Hong Zhou, Jialin Deng, Qian Wu, Yule Zeng, Tianyao Wang, Jiayi Wu, Xiaomei Duan, Beisha Tang, Xinhua Wei, Lu He, Feng Liu · 2026
Read Shared genetic architecture between DTI‐ALPS traits and neurodegenerative diseases by Hong Zhou, Jialin Deng, Qian Wu, Yule Zeng, Tianyao Wang, Jiayi Wu, Xiaomei Duan, Beisha Tang, Xinhua Wei, Lu He, Feng Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13554997.txt.
Description
Hong Zhou and co-authors hunt for genes shared between the brain's drainage gauge and its degenerative diseases in a 2026 study. A brain imaging index, DTI-ALPS, estimates how well fluid moves along the spaces around blood vessels, the brain's rinse cycle. The index tracks with neurodegenerative disease, but whether the link is written in DNA was unknown.
The team wove together genome-wide datasets for three drainage traits and seven diseases. Overlap turned out widespread yet uneven. Twenty-two genomic loci were shared, including fresh candidates near two genes never tied to this story, with the strongest meeting point on chromosome seventeen. The shared loci mapped to one hundred eighty-three protein-coding genes, concentrated in the cell's recycling system and its internal scaffolding. Forty-five genes answered to both sides. The authors read the overlap as shared machinery, not coincidence.
Catalog record
| CREATOR | Hong Zhou, Jialin Deng, Qian Wu, Yule Zeng, Tianyao Wang, Jiayi Wu, Xiaomei Duan, Beisha Tang, Xinhua Wei, Lu He, Feng Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |