Algorithm-guided personalized pulsed field ablation for persistent atrial fibrillation: a prospective multicentre study with matched external comparison
Frédéric Anselme, Decebal Gabriel Lațcu, Théo Méral, Arnaud Savoure, Serge Boveda, Pascal Defaye, Sandrine Venier, Grégoire Massoullié, Pierre Ollitrault, Olivier Thomas, Raphaël Al Hamoud, Maria-Alexandra Nicola, Corentin Chaumont · 2026
Read Algorithm-guided personalized pulsed field ablation for persistent atrial fibrillation: a prospective multicentre study with matched external comparison by Frédéric Anselme, Decebal Gabriel Lațcu, Théo Méral, Arnaud Savoure, Serge Boveda, Pascal Defaye, Sandrine Venier, Grégoire Massoullié, Pierre Ollitrault, Olivier Thomas, Raphaël Al Hamoud, Maria-Alexandra Nicola, Corentin Chaumont (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13554798.txt.
Description
Frédéric Anselme and co-authors let an algorithm choose where to ablate a stubborn racing heart in a 2026 study. Persistent atrial fibrillation returns often after the standard fix, isolating the pulmonary veins, and extra burn patterns have disappointed. A deterministic algorithm that reads the heart's own electrical signals promises personalization without chaos: it flags electrograms whose shape repeats, cycle after cycle, as candidate drivers worth ablating.
Fifty consecutive patients at two centers, all in fibrillation when the procedure began, had their left atria mapped in dense detail, tens of thousands of points each. The algorithm's targets joined vein isolation in a pulsed-field ablation plan. Outcomes were matched against an external cohort treated with vein plus posterior wall isolation by the same energy. The paper reports feasibility, safety, and rhythm results for the guided strategy, testing whether algorithmic patience beats anatomical habit.
Catalog record
| CREATOR | Frédéric Anselme, Decebal Gabriel Lațcu, Théo Méral, Arnaud Savoure, Serge Boveda, Pascal Defaye, Sandrine Venier, Grégoire Massoullié, Pierre Ollitrault, Olivier Thomas, Raphaël Al Hamoud, Maria-Alexandra Nicola, Corentin Chaumont |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 8 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |