NR3C1/PRKACG-mediated impairment of mitochondrial quality control underlies stress-induced hypothalamic neuronal injury
Guowei Zhang, Jingze Cong, Xiaowei Feng, Hongjian Xin, Weihao Zhu, Rui Shi, Chenyu Li, Yang Wang, Rufei Ma, Yingmin Li, Bin Cong, Weibo Shi · 2026
Read NR3C1/PRKACG-mediated impairment of mitochondrial quality control underlies stress-induced hypothalamic neuronal injury by Guowei Zhang, Jingze Cong, Xiaowei Feng, Hongjian Xin, Weihao Zhu, Rui Shi, Chenyu Li, Yang Wang, Rufei Ma, Yingmin Li, Bin Cong, Weibo Shi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13554088.txt.
Description
Guowei Zhang and colleagues traced how stress damages neurons in the brain's hypothalamus through failing mitochondrial quality control, publishing the study in 2026. The hypothalamus coordinates hormonal and bodily stress responses, and its injury is linked to many diseases, yet the molecular chain was unclear. Using rat models of short and long stress, the team examined mitochondrial shape, turnover, and the signalling that governs them.
Stress pushed mitochondria toward excess splitting and away from fusion, while stress hormones, acting through their receptor, switched off a protein kinase gene and cut a key phosphorylation step. Short and long stress also triggered different clean-up pathways, depleting mitochondria, and prolonged stress shifted cell death from one form to another. The findings name a candidate mechanism for stress-linked brain injury and future treatment research.
Catalog record
| CREATOR | Guowei Zhang, Jingze Cong, Xiaowei Feng, Hongjian Xin, Weihao Zhu, Rui Shi, Chenyu Li, Yang Wang, Rufei Ma, Yingmin Li, Bin Cong, Weibo Shi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |