In vitro priming with Mycobacterium fortuitum induces trained immunity-associated phenotypes in caprine alveolar macrophages and enhances phagosomal maturation and antimicrobial functions upon homologous re-stimulation
Miriam Blay-Benach, Patricia Cuenca-Lara, Julia Moraleda, Zoraida Cervera, Joan Repullés, Bernat Pérez de Val · 2026
Read In vitro priming with Mycobacterium fortuitum induces trained immunity-associated phenotypes in caprine alveolar macrophages and enhances phagosomal maturation and antimicrobial functions upon homologous re-stimulation by Miriam Blay-Benach, Patricia Cuenca-Lara, Julia Moraleda, Zoraida Cervera, Joan Repullés, Bernat Pérez de Val (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13553504.txt.
Description
Six researchers test trained immunity in goat lung cells in a 2026 paper. Trained immunity is a lasting shift in first line immune cells that makes them react more strongly later. Lung macrophages form the main barrier where air meets the body, so they are a prime target.
Cells were primed in a dish with a mild mycobacterium, rested, then met the same germ again. Primed cells made more signal proteins and more of a germ killing enzyme than fresh cells. Their inner compartments also turned acidic faster and stayed that way, a sign of stronger germ handling. The team offers the work as proof the training effect can be raised in this cell type.
Catalog record
| CREATOR | Miriam Blay-Benach, Patricia Cuenca-Lara, Julia Moraleda, Zoraida Cervera, Joan Repullés, Bernat Pérez de Val |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |