Infectious, inflammatory, and clinical outcomes among patients prescribed trifluoperazine or amoxapine: a retrospective cohort study using real-world data
Omar Malik, Jorge Rodriguez-Fernandez, Aliu Opeyemi Yakubu, Wedad Farrag, Ernesto G. Miranda-Morales, Sara M. Dann, Ashok K. Chopra, Xiang Fang · 2026
Read Infectious, inflammatory, and clinical outcomes among patients prescribed trifluoperazine or amoxapine: a retrospective cohort study using real-world data by Omar Malik, Jorge Rodriguez-Fernandez, Aliu Opeyemi Yakubu, Wedad Farrag, Ernesto G. Miranda-Morales, Sara M. Dann, Ashok K. Chopra, Xiang Fang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13553449.txt.
Description
Omar Malik and co-authors check whether two older psychiatric drugs change infection risk in real patients, in a 2026 study. New antibiotics are scarce, so repurposing draws interest. Lab work hints these drugs fight germs or calm immunity. Their clinical effects on infection were unknown. The team used a federated health record network. It covers over seventy-five million patients. Users of each drug were matched against comparison groups.
About twenty-two hundred users of the first drug qualified. The second drug had about eight hundred users. The first drug linked to far fewer ear, nose, throat, and dental infections. That held across all age groups. It also linked to raised white cell counts. Lower COVID-19 rates appeared mainly in older adults. Inflammation markers, intensive care use, and death were tracked too. The authors present the study as a real-world signal hunt. Trials would be needed to test cause.
Catalog record
| CREATOR | Omar Malik, Jorge Rodriguez-Fernandez, Aliu Opeyemi Yakubu, Wedad Farrag, Ernesto G. Miranda-Morales, Sara M. Dann, Ashok K. Chopra, Xiang Fang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |