Multi-platform evidence of GSDMD-dependent pyroptosis in malaria with a potential role for TLR7
Yumei Gong, Yiwei Liu, Longkun Li, Jialin Geng, Ying Huang, Lixin Luo, Xinyue Wang, Long Xu, Yongtao Zhang, Xingfei Pan, Lu Li, Shan Zhao, Jun Huang · 2026
Read Multi-platform evidence of GSDMD-dependent pyroptosis in malaria with a potential role for TLR7 by Yumei Gong, Yiwei Liu, Longkun Li, Jialin Geng, Ying Huang, Lixin Luo, Xinyue Wang, Long Xu, Yongtao Zhang, Xingfei Pan, Lu Li, Shan Zhao, Jun Huang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13553252.txt.
Description
Yumei Gong and co-authors trace a fiery form of cell death in malaria in a 2026 paper. In malaria, spleen macrophages drive much of the inflammation that harms the host. One of their weapons, pyroptosis, bursts cells open to release alarm signals; too much of it damages tissue. The team combined patient gene data, a mouse malaria model, and lab macrophage tests to map the pathway.
Genes of the pyroptosis machinery ran high in patients. In infected mice, both known trigger routes fired in spleen macrophages, ending in the pore-forming protein GSDMD. Debris from infected red cells alone could trip the switch in the dish. A drug that stimulates the TLR7 sensor calmed the bursting, above all on one route. The authors propose TLR7 as a brake worth exploring.
Catalog record
| CREATOR | Yumei Gong, Yiwei Liu, Longkun Li, Jialin Geng, Ying Huang, Lixin Luo, Xinyue Wang, Long Xu, Yongtao Zhang, Xingfei Pan, Lu Li, Shan Zhao, Jun Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |