Cigarette smoke and e-cigarette aerosol extracts induce myelopoiesis and suppress inflammatory cytokine production
Jeanette Y C Sullivan, Helen X Huang, Jianhong C Heidmann, Francisco Diaz, Camille Brzechffa, Jane H Chen, Eli M Soyfer, Nneamaka Iwobi, Irene Hasen, Amanda Ting, Nicole Sparks, Michael T Kleinman, Angela G Fleischman · 2026
Read Cigarette smoke and e-cigarette aerosol extracts induce myelopoiesis and suppress inflammatory cytokine production by Jeanette Y C Sullivan, Helen X Huang, Jianhong C Heidmann, Francisco Diaz, Camille Brzechffa, Jane H Chen, Eli M Soyfer, Nneamaka Iwobi, Irene Hasen, Amanda Ting, Nicole Sparks, Michael T Kleinman, Angela G Fleischman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13553112.txt.
Description
Jeanette Sullivan and co-authors compare cigarette smoke and e-cigarette vapor across the blood-forming system. Both are known to disturb immunity, but side-by-side maps were missing. Their 2026 study treats several macrophage models with standardized extracts. Smoke extract reliably damped a key inflammatory signal, and the damping grew with dose. Vapor alone barely moved it. Smoke also turned macrophages into foam cells through an oxidative route.
Both extracts curbed the colony growth of blood stem and progenitor cells. In mice, smoke followed by vapor, a common real-world pattern, raised platelet counts and myeloid cell share. Quitting alone did not show those shifts. The myeloid skew persisted beyond exposure, hinting at lasting marrow reprogramming.
Catalog record
| CREATOR | Jeanette Y C Sullivan, Helen X Huang, Jianhong C Heidmann, Francisco Diaz, Camille Brzechffa, Jane H Chen, Eli M Soyfer, Nneamaka Iwobi, Irene Hasen, Amanda Ting, Nicole Sparks, Michael T Kleinman, Angela G Fleischman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |