Genetic evidence and cross-species functional characterization implicate CNN2 in age-related macular degeneration susceptibility
Fei-Fei Cheng, Hao Mou, Zhenyu Liu, Chang-Jun Zhang, You-Yuan Zhuang, Zhen Wu, Xin-Ran Wen, Angli Xue, Xiao Zhang, Jian Yang, Zi-Bing Jin · 2026
Read Genetic evidence and cross-species functional characterization implicate CNN2 in age-related macular degeneration susceptibility by Fei-Fei Cheng, Hao Mou, Zhenyu Liu, Chang-Jun Zhang, You-Yuan Zhuang, Zhen Wu, Xin-Ran Wen, Angli Xue, Xiao Zhang, Jian Yang, Zi-Bing Jin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13552911.txt.
Description
Fei-Fei Cheng and co-authors hunt for genes behind age-related macular degeneration, in a 2026 study. The disease is a top cause of lasting vision loss in older people. Large gene scans have flagged many risk spots, but the genes at most spots are unknown. The team joined gene activity data with the scan results.
Nine candidate genes rose to the top. Tests in zebrafish showed that lowering two of them harmed eye structure and vision. Mouse studies confirmed that one gene, CNN2, supports the light-sensing cells and contrast vision. The gene is active mainly in vessel cells of the eye. Cross-species checks of this kind turn vague risk spots into named targets.
Catalog record
| CREATOR | Fei-Fei Cheng, Hao Mou, Zhenyu Liu, Chang-Jun Zhang, You-Yuan Zhuang, Zhen Wu, Xin-Ran Wen, Angli Xue, Xiao Zhang, Jian Yang, Zi-Bing Jin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |