Characterization of DNA methylation in PBMCs and donor-matched iPSCs shows age-related methylation is reset during stem cell reprogramming
Xylena Reed, Cory A Weller, Sara Saez-Atienzar, Alexandra Beilina, Sultana Solaiman, Makayla Portley, Mary Kaileh, Roshni Roy, Jinhui Ding, A Zenobia Moore, D Thad Whitaker, Bryan J Traynor, Luigi Ferrucci, J Raphael Gibbs, Sonja W Scholz, Mark R Cookson, Gabriele Saretzki · 2026
Read Characterization of DNA methylation in PBMCs and donor-matched iPSCs shows age-related methylation is reset during stem cell reprogramming by Xylena Reed, Cory A Weller, Sara Saez-Atienzar, Alexandra Beilina, Sultana Solaiman, Makayla Portley, Mary Kaileh, Roshni Roy, Jinhui Ding, A Zenobia Moore, D Thad Whitaker, Bryan J Traynor, Luigi Ferrucci, J Raphael Gibbs, Sonja W Scholz, Mark R Cookson, Gabriele Saretzki (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13552744.txt.
Description
Xylena Reed and co-authors present a 2026 study on whether aging marks on DNA survive the reprogramming of blood cells into stem cells. Chemical tags on DNA shift with age and shape how cells work. Stem cells made from a person's own cells are widely used in research, so it matters whether they keep the donor's age marks or reset them.
The team took blood cells from 99 healthy adults in an aging study and reprogrammed them into stem cells. Genome-wide tag maps were then compared between the two cell types. Age-related tags were largely reset by reprogramming. The result supports using such stem cells to study disease without age as a built-in bias.
Catalog record
| CREATOR | Xylena Reed, Cory A Weller, Sara Saez-Atienzar, Alexandra Beilina, Sultana Solaiman, Makayla Portley, Mary Kaileh, Roshni Roy, Jinhui Ding, A Zenobia Moore, D Thad Whitaker, Bryan J Traynor, Luigi Ferrucci, J Raphael Gibbs, Sonja W Scholz, Mark R Cookson, Gabriele Saretzki |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |