Salmonella lipopolysaccharide stimulates uptake of long-chain fatty acids in the small intestine
Eugene Koo, Gabriella Quinn, Cassie L. Behrendt, Brian Hassell, Katie N. Kang, Kelly A. Ruhn, Gonçalo Vale, Jeffrey G. McDonald, Wenhan Zhu, Sebastian E. Winter, Lora V. Hooper · 2026
Read Salmonella lipopolysaccharide stimulates uptake of long-chain fatty acids in the small intestine by Eugene Koo, Gabriella Quinn, Cassie L. Behrendt, Brian Hassell, Katie N. Kang, Kelly A. Ruhn, Gonçalo Vale, Jeffrey G. McDonald, Wenhan Zhu, Sebastian E. Winter, Lora V. Hooper (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13552659.txt.
Description
Gut bacteria do more than crowd the intestine; their surface molecules can retune how the host eats. Eugene Koo and ten co-authors show in this 2026 study that Salmonella infection makes the mouse small intestine absorb more long-chain fat. The effect came with higher activity in the genes that pull fat in, and it vanished without the fat transporter CD36.
The trigger was the bacterium's outer coat molecule, LPS, sensed by an immune receptor on support cells; even a friendly gut resident provoked a weaker version of the same response. Mutants with altered coats lost the power. Blocking fat uptake left the animals worse at fighting the infection, hinting the response is a defense, perhaps feeding immune cells under attack. The work names a bacterial signal as a dial on dietary fat uptake.
Catalog record
| CREATOR | Eugene Koo, Gabriella Quinn, Cassie L. Behrendt, Brian Hassell, Katie N. Kang, Kelly A. Ruhn, Gonçalo Vale, Jeffrey G. McDonald, Wenhan Zhu, Sebastian E. Winter, Lora V. Hooper |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |