Characterization of the Pharmacokinetics and Physiological Effects of Tapentadol in Horses
Annabella D Lynch, Khursheed R Mama, Dan S McKemie, Phillip H Kass, Heather K Knych · 2026
Read Characterization of the Pharmacokinetics and Physiological Effects of Tapentadol in Horses by Annabella D Lynch, Khursheed R Mama, Dan S McKemie, Phillip H Kass, Heather K Knych (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13552515.txt.
Description
Annabella D Lynch, leading four colleagues, published a 2026 study of tapentadol, a dual-action pain drug, as a candidate analgesic for horses. Six horses received three escalating single oral doses and one intravenous dose in a four-period design, with blood levels of the drug and its main breakdown product measured by mass spectrometry.
Oral doses peaked in blood within about an hour, faster at higher doses, and peak levels rose steeply and variably with dose in the reported means. The breakdown product reached far higher levels than the parent drug after oral dosing and peaked much later, reflecting gut and liver processing. Tapentadol was well tolerated at every dose tested, and the authors supply the numbers needed to design dosing studies for equine pain.
Catalog record
| CREATOR | Annabella D Lynch, Khursheed R Mama, Dan S McKemie, Phillip H Kass, Heather K Knych |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44298 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |