Pharmacokinetics of Diclazuril in the Plasma and Cerebrospinal Fluid of Healthy Adult Horses After a Single Oral Dose Administered as a Pelleted Topdressing
Elizabeth J Treece, Kate L Hepworth‐Warren, Mark G Papich, Philip D van Harreveld, Anthony T Blikslager, Faith E Church, Kaitlyn B Harbor, Sara J Erwin‐Craig · 2026
Read Pharmacokinetics of Diclazuril in the Plasma and Cerebrospinal Fluid of Healthy Adult Horses After a Single Oral Dose Administered as a Pelleted Topdressing by Elizabeth J Treece, Kate L Hepworth‐Warren, Mark G Papich, Philip D van Harreveld, Anthony T Blikslager, Faith E Church, Kaitlyn B Harbor, Sara J Erwin‐Craig (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13552514.txt.
Description
Elizabeth Treece and co-authors time an anti-protozoal drug's path into horse spinal fluid in this 2026 paper. The drug, diclazuril, treats a neurologic disease caused by a parasite. Six healthy horses got a single dose mixed into sweet feed. Blood and spinal fluid were sampled for eight days.
Spinal fluid levels crossed the parasite-killing threshold twelve hours after dosing. They stayed above it for the whole sampling window. Fluid levels peaked at one day, while blood levels peaked at two days. The blood peak ran far higher than the fluid peak, as expected for a drug crossing into the nervous system. The authors support prompt dosing when the disease is suspected.
Catalog record
| CREATOR | Elizabeth J Treece, Kate L Hepworth‐Warren, Mark G Papich, Philip D van Harreveld, Anthony T Blikslager, Faith E Church, Kaitlyn B Harbor, Sara J Erwin‐Craig |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |