Pharmacokinetics of Orally Administered Clonidine in Dogs
Kevin Pflaum, Julia Albright, Sherry Cox, Joe Smith · 2026
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Description
Kevin Pflaum, Julia Albright, Sherry Cox, and Joe Smith published a 2026 study of a calming drug in dogs. The drug, clonidine, is used for fear-based problems in dogs. Vets see it as short-acting, yet dog data were lacking. Six lab beagles got one oral dose of the standard form. Blood levels were tracked over the hours after dosing. Sedation scores and heart rate were watched too.
Blood levels peaked at about one and a half to two hours. They fell below lab detection within four to eight hours. The half-life was short, at well under an hour in the reported figures. All dogs showed slight drops in heart rate. Sedation scores rose a bit in all dogs. No other side effects appeared at this dose, and the team calls the dose well tolerated.
Catalog record
| CREATOR | Kevin Pflaum, Julia Albright, Sherry Cox, Joe Smith |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27087 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |