The Impact of S‐220–Loaded Silk Hydrogels on In Vitro Neurite Outgrowth in 2 and 3 Dimensions
Hongming Ma, F Philipp Seib, Wenlong Huang · 2026
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Description
Hongming Ma, Philipp Seib, and Wenlong Huang grow nerve cells on silk gels in this 2026 study. Silk hydrogels are soft, body-friendly scaffolds for lab-grown tissue. A compound called S-220 switches on a cell pathway known to spur nerve fiber growth. The team tested the gel and the compound together, in flat and in three-dimensional cultures.
The compound alone lengthened nerve fibers in a dose-linked way. Silk gel alone matched standard surfaces, showing it harms nothing. Mixing the compound into the gel, though, shortened fibers instead of helping. Three-dimensional cultures grew shorter but more richly branched fibers. The gel works as a base, but drug delivery needs a different route.
Catalog record
| CREATOR | Hongming Ma, F Philipp Seib, Wenlong Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |