Tumor markers in rheumatoid arthritis -associated interstitial lung disease: a systematic review and meta-analysis
Zeng Qiaoqian, Wu Qing, Li Bowen, Wei Qijiao, Wang Na · 2026
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Description
Zeng Qiaoqian, Wu Qing, Li Bowen, Wei Qijiao, and Wang Na published a 2026 systematic review and meta-analysis of tumor markers repurposed to detect lung scarring in rheumatoid arthritis. Interstitial lung disease is a leading killer in this arthritis, and blood markers could complement imaging. The team searched six databases to April 2025 for studies comparing marker levels between arthritis patients with and without lung disease, rating quality with a standard scale.
Thirty-six studies with 7,300 patients entered the synthesis. Eight markers, including CA125, CA199, and CEA, ran significantly higher in lung disease in the pooled results reported, and two markers, KL-6 and CYFRA21-1, discriminated the condition best. Evidence came mainly from Chinese cohorts, so the authors propose a multi-marker panel pending wider validation.
Catalog record
| CREATOR | Zeng Qiaoqian, Wu Qing, Li Bowen, Wei Qijiao, Wang Na |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53417 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |