Screening and identification of the ncRNA-mRNA regulatory network associated with DNA methylation in goose embryonic myoblasts
Yongquan Luo, Pufei Hong, Tiande Chen, Yong Li, Yuanhao Han, Kaiyue Chang, Ziyang Liu, Xiujin Li, Yunmao Huang, Yunbo Tian, Zhongping Wu, Xumeng Zhang · 2026
Read Screening and identification of the ncRNA-mRNA regulatory network associated with DNA methylation in goose embryonic myoblasts by Yongquan Luo, Pufei Hong, Tiande Chen, Yong Li, Yuanhao Han, Kaiyue Chang, Ziyang Liu, Xiujin Li, Yunmao Huang, Yunbo Tian, Zhongping Wu, Xumeng Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13551957.txt.
Description
A 2026 study by Yongquan Luo and eleven colleagues examined gene regulation by DNA methylation in goose embryonic muscle cells. Two local goose breeds grow at different rates, hinting at shared regulatory machinery. Working with cells from the fast-growing Magang goose, the team applied one drug that blocks methylation and another that blocks its removal, then sequenced the full RNA output.
The methylation blocker boosted cell proliferation and differentiation, while the removal blocker suppressed both, confirming methylation's grip on muscle cell fate in the reported experiments. Thousands of RNAs shifted, and the authors assembled a competing regulatory network of long RNAs, circular RNAs, microRNAs, and genes. One microRNA emerged as a key brake on development through a cell-cycle gene, validated by a reporter test.
Catalog record
| CREATOR | Yongquan Luo, Pufei Hong, Tiande Chen, Yong Li, Yuanhao Han, Kaiyue Chang, Ziyang Liu, Xiujin Li, Yunmao Huang, Yunbo Tian, Zhongping Wu, Xumeng Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 87157 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |