Targeting the neuro–immune axis: immunological mechanisms and therapeutic strategies in male sexual dysfunction
Zheng Hu, Jun Luo, Jianyun Lou, Juntao Deng, Zi tao Gong, Jinming Chen · 2026
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Description
Zheng Hu, leading five colleagues, published a 2026 review proposing that disrupted talk between nerves and the immune system unifies many cases of male sexual dysfunction. Traditional explanations stress blood vessels, hormones, and psychology, yet the authors gather evidence that neural injury and chronic inflammation feed each other. Their framework treats neuro-immune disruption as a shared pathway behind causes from diabetic nerve damage to chronic pelvic pain.
Immune activity worsens nerve and vessel damage, which in turn sustains inflammation, forming a self-perpetuating cycle in the authors' model. They explore nerve-targeted treatments such as sacral neuromodulation and vagus nerve stimulation, borrowed from pain and autoimmune fields, as ways to restore balance. Direct clinical evidence in sexual dysfunction remains limited, so the review charts a research agenda.
Catalog record
| CREATOR | Zheng Hu, Jun Luo, Jianyun Lou, Juntao Deng, Zi tao Gong, Jinming Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55460 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |