EV-transferred miR-7111-3p inhibits malignant phenotypes and tumor growth in nasopharyngeal carcinoma via targeting APP-regulated epithelial-mesenchymal transition
Hejing Huang, Zhehao Xiao, Weiling Chen, Zhao Li, Xuxia Chen, Xiaohui Yang, Xiaojun Chen, Ziman Luo, Huining Chen, Song Qu · 2026
Read EV-transferred miR-7111-3p inhibits malignant phenotypes and tumor growth in nasopharyngeal carcinoma via targeting APP-regulated epithelial-mesenchymal transition by Hejing Huang, Zhehao Xiao, Weiling Chen, Zhao Li, Xuxia Chen, Xiaohui Yang, Xiaojun Chen, Ziman Luo, Huining Chen, Song Qu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13551778.txt.
Description
Huang and co-authors identify a tiny RNA shipped between cells that restrains a head and neck cancer. Their 2026 paper studies miR-7111-3p in nasopharyngeal carcinoma, where the molecule was scarce in patient serum and tumour cell lines. The team adjusted its levels in cells and mouse tumours, traced its delivery inside extracellular vesicles, the membrane parcels cells use to exchange cargo, and hunted its gene targets.
Raising the microRNA suppressed proliferation, migration, invasion, and the shape-shifting transition that helps cancers spread, while lowering it did the reverse. Its direct target proved to be amyloid precursor protein, better known from brain disease; restoring that protein cancelled the microRNA's benefits. Vesicles from microRNA-poor tumour cells raised the target and growth in recipient cells. In mice, extra microRNA shrank grafted tumours. The authors name the axis a therapeutic target.
Catalog record
| CREATOR | Hejing Huang, Zhehao Xiao, Weiling Chen, Zhao Li, Xuxia Chen, Xiaohui Yang, Xiaojun Chen, Ziman Luo, Huining Chen, Song Qu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |