Extracellular vesicles from plasma of patients with minimal hepatic encephalopathy induce neuroinflammation and cognitive impairment in rats, which are prevented by treating the patients with rifaximin
Adria Lopez-Gramaje, Yaiza M. Arenas, Juan-José Gallego, Paula Izquierdo-Altarejos, Amparo Urios, Desamparados Escudero-García, Salvador Benlloch, Elena Kosenko, Vicente Felipo, Carmina Montoliu · 2026
Read Extracellular vesicles from plasma of patients with minimal hepatic encephalopathy induce neuroinflammation and cognitive impairment in rats, which are prevented by treating the patients with rifaximin by Adria Lopez-Gramaje, Yaiza M. Arenas, Juan-José Gallego, Paula Izquierdo-Altarejos, Amparo Urios, Desamparados Escudero-García, Salvador Benlloch, Elena Kosenko, Vicente Felipo, Carmina Montoliu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13551777.txt.
Description
Adria Lopez-Gramaje, with nine colleagues, published a 2026 study of how liver disease dulls thought. In cirrhosis, a mild brain disorder follows a shift toward inflammation in the body. A drug called rifaximin can reverse that shift. The team took tiny packets shed into blood, called vesicles, from patients. They injected the packets into rats and tested the rats' thinking and brains.
Packets from sick patients carried more of a key inflammatory protein. They caused strong thinking harm in rats. Brain inflammation rose, and glutamate receptors shifted in the memory center. Packets from drug-treated patients lost the extra cargo. They also lost the harmful effect. The team argues the packets carry the signal from body to brain.
Catalog record
| CREATOR | Adria Lopez-Gramaje, Yaiza M. Arenas, Juan-José Gallego, Paula Izquierdo-Altarejos, Amparo Urios, Desamparados Escudero-García, Salvador Benlloch, Elena Kosenko, Vicente Felipo, Carmina Montoliu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54970 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |