Protective effects of Tinospora crispa and Tinospora cordifolia extracts against methylglyoxal-induced oxidative stress and apoptosis in hFOB 1.19 cells: ELISA-based evaluation and molecular docking insights with antioxidant enzymes
Luqman Jaya, Gabriele Ruth Anisah Froemming, Zunika Amit · 2026
Read Protective effects of Tinospora crispa and Tinospora cordifolia extracts against methylglyoxal-induced oxidative stress and apoptosis in hFOB 1.19 cells: ELISA-based evaluation and molecular docking insights with antioxidant enzymes by Luqman Jaya, Gabriele Ruth Anisah Froemming, Zunika Amit (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13551757.txt.
Description
Luqman Jaya, Gabriele Ruth Anisah Froemming, and Zunika Amit published a 2026 laboratory study of two Tinospora plant extracts as shields for bone-forming cells. Methylglyoxal, a reactive compound, drives oxidative stress and cell death in osteoblasts, disturbing bone balance. The team treated a human osteoblast cell line with methanolic and aqueous extracts, measuring reactive oxygen species, a death enzyme, and glycation products, plus computer docking of plant compounds against enzymes.
Methanolic extracts of both species cut reactive oxygen levels by over forty percent at the reported doses and lowered the death enzyme caspase-3. Only certain extracts reduced glycation products, suggesting selective action. Docking showed berberine binding strongly to two target proteins, supporting the extracts as candidate protectors against this form of bone cell damage.
Catalog record
| CREATOR | Luqman Jaya, Gabriele Ruth Anisah Froemming, Zunika Amit |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43607 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |