Neuro–immune crosstalk in the tumor microenvironment: mechanisms and therapeutic implications for cancer immunotherapy
Zezhi Fan, Na Wang, Bo Zhang, Kaiyuan Deng, Jiangjiang Fu, Li Ma, Junyi Li, Zhifang Xu, Yi Guo · 2026
Read Neuro–immune crosstalk in the tumor microenvironment: mechanisms and therapeutic implications for cancer immunotherapy by Zezhi Fan, Na Wang, Bo Zhang, Kaiyuan Deng, Jiangjiang Fu, Li Ma, Junyi Li, Zhifang Xu, Yi Guo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13551695.txt.
Description
Zezhi Fan, leading eight colleagues, published a 2026 review of how nerves and the immune system talk to each other inside tumors. Neural signals reach cancer and support cells through synapse-like contacts and chemical messengers, shaping immune behavior. The review gathers evidence that this traffic can exhaust killer T cells, expand suppressive populations, and help tumors resist immunotherapy.
The influence runs both ways: tumor signals remodel neural activity, forming a regulatory network the authors call neuro-immune-tumor crosstalk. How neural, immune, and metabolic pathways integrate remains incompletely understood, and a young field called cancer neuroscience has formed around the question. Proposed responses include nerve modulation, neuroactive drugs, and combinations with immunotherapy to sharpen precision treatment.
Catalog record
| CREATOR | Zezhi Fan, Na Wang, Bo Zhang, Kaiyuan Deng, Jiangjiang Fu, Li Ma, Junyi Li, Zhifang Xu, Yi Guo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 102332 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |