Roux-en-Y gastric bypass promotes white adipose tissue browning and systemic metabolic recovery in obese type 2 diabetic mice
Tengfei Qi, Ru Ji, Liangping Wu, Jipei He, Hongbin Zhang, Zhengyong Xie · 2026
Read Roux-en-Y gastric bypass promotes white adipose tissue browning and systemic metabolic recovery in obese type 2 diabetic mice by Tengfei Qi, Ru Ji, Liangping Wu, Jipei He, Hongbin Zhang, Zhengyong Xie (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13551693.txt.
Description
Tengfei Qi, leading five colleagues, published a 2026 mouse study of how gastric bypass surgery reshapes fat tissue. Roux-en-Y bypass reliably improves obesity and type 2 diabetes, yet the fat changes behind that benefit are incompletely understood. Obese diabetic mice were assigned to bypass, sham surgery, or no surgery, then followed for eight weeks with body composition scans and tissue examination.
Bypass mice lost weight steadily, normalized blood sugar, and improved insulin sensitivity and blood lipids, losing fat while preserving lean mass. Their white fat cells shrank across depots, a pattern the authors read as browning toward a more active, brown-like state, while brown fat reversed its obesity-related whitening. Liver fat also eased, supporting fat plasticity as a central mechanism.
Catalog record
| CREATOR | Tengfei Qi, Ru Ji, Liangping Wu, Jipei He, Hongbin Zhang, Zhengyong Xie |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45488 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |