Therapeutic mRNA vaccines for lung cancer: reshaping the tumor microenvironment to enhance anti-tumor immunity
Hao Wu, Ruiqi Weng, Siyi Gu, Jiyuan Wang, Xiaoyan Ma, Jiaxuan Li, Xiaotian Tie, Chongmin Huang, Keda Chen · 2026
Read Therapeutic mRNA vaccines for lung cancer: reshaping the tumor microenvironment to enhance anti-tumor immunity by Hao Wu, Ruiqi Weng, Siyi Gu, Jiyuan Wang, Xiaoyan Ma, Jiaxuan Li, Xiaotian Tie, Chongmin Huang, Keda Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13551553.txt.
Description
Hao Wu and eight co-authors review mRNA vaccines as a treatment for lung cancer in a 2026 paper. Standard care, from surgery to targeted drugs and immune therapy, is limited by resistance, modest benefit, and side effects.
An mRNA vaccine delivers instructions for making a tumor marker inside the body. The immune system then learns to attack cells carrying that marker. The review explains how the vaccines also reshape the tissue around the tumor, both directly and through the T-cell response they spark. That reshaping can turn a cold tumor into one the immune system can fight. The authors survey progress so far and the hurdles ahead for this fast-moving approach.
Catalog record
| CREATOR | Hao Wu, Ruiqi Weng, Siyi Gu, Jiyuan Wang, Xiaoyan Ma, Jiaxuan Li, Xiaotian Tie, Chongmin Huang, Keda Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |