Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola
Heidi Espadas‐Álvarez, Verónica Valverde‐Garduño · 2026
Read Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola by Heidi Espadas‐Álvarez, Verónica Valverde‐Garduño (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13551534.txt.
Description
Heidi Espadas-Álvarez and Verónica Valverde-Garduño published a 2026 study of a gene switch in a malaria mosquito. The species, Anopheles albimanus, spreads malaria in the Americas. A switch called lola had been spotted near immune genes in a related species. The team weakened lola in live mosquitoes. They then tracked survival and gene activity after infection.
Mosquitoes with weak lola died more readily from germs. Many defense genes failed to switch on without it. The affected genes make germ-killing proteins and sensing proteins. Others make or clean up reactive oxygen, a harsh cell chemical. A signaling path called JNK was hit too. The team says lola runs much of the mosquito's defense.
Catalog record
| CREATOR | Heidi Espadas‐Álvarez, Verónica Valverde‐Garduño |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70170 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |