Cardiovascular Organoids With Adjustable Endothelial Composition via SOX17‐Engineered hPSCs
Po‐Yu Liang, Gyuhyung Jin, Nathan R Petrucci, Xiaojun Lance Lian, Xiaoping Bao · 2026
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Description
Po-Yu Liang, with four colleagues, published a 2026 study building heart organoids whose blood vessel cell share can be dialed up or down. Organoids are tiny lab-grown tissue models, and heart versions need the right mix of muscle and endothelial cells, which line vessels. The team edited human pluripotent stem cells so a gene called SOX17 could be switched on, steering cells toward endothelial identity.
The resulting organoids showed heart-like structure and controllable composition. A chemotherapy drug, doxorubicin, reduced their viability and beating, matching known heart toxicity, while freezing injury mimicked a heart attack and a common drug softened the damage. Another drug raised calcium signals as expected, supporting the model for disease and drug testing.
Catalog record
| CREATOR | Po‐Yu Liang, Gyuhyung Jin, Nathan R Petrucci, Xiaojun Lance Lian, Xiaoping Bao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32676 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |