Organ preservation after neoadjuvant immunotherapy in mismatch repair-deficient colorectal cancer: response assessment, watch-and-wait, and salvage surgery
Nan Yao, Guoshuai Xu, Ning Duan, Fuzhou Han, Wenqiang Li, Jun Qu · 2026
Read Organ preservation after neoadjuvant immunotherapy in mismatch repair-deficient colorectal cancer: response assessment, watch-and-wait, and salvage surgery by Nan Yao, Guoshuai Xu, Ning Duan, Fuzhou Han, Wenqiang Li, Jun Qu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13551423.txt.
Description
Nan Yao and co-authors present a 2026 review on sparing organs after immune therapy for a subtype of colorectal cancer. These tumors lack mismatch repair, and checkpoint drugs given before surgery melt many of them away. The review asks when surgeons can safely skip the operation and watch instead.
For colon tumors, the evidence still rests on what pathologists find after removal, and nonoperative checks are unproven. Rectal tumors are different: response can be rechecked by exam, scope, and MRI over time. In highly chosen patients with a complete clinical response, watch-and-wait may be fair. The authors weigh salvage surgery, surveillance burdens, side effects, and open disputes. They urge caution outside expert centers.
Catalog record
| CREATOR | Nan Yao, Guoshuai Xu, Ning Duan, Fuzhou Han, Wenqiang Li, Jun Qu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |