Pharmacokinetics of Intravenous Melatonin in Preschool‐Aged Pediatric Surgical Patients
Anne Louise de Barros Garioud, Arash Afshari, Lau Romlund Halgreen, Kristian Østergaard Nielsen, Lars Peter Kloster Andersen · 2026
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Description
Anne Louise de Barros Garioud and four colleagues reported in 2026 on how intravenous melatonin behaves in young children's bodies during surgery. Melatonin may ease anxiety, pain, and delirium around operations, yet dosing data in small children were sparse. Twenty children aged 1 to 6 having elective surgery under general anesthesia received a weight-based dose before surgery ended, with six blood samples each.
Peak blood levels were high and the drug cleared with a half-life near 35 minutes in the reported analysis, values the authors compare with adult data. No emergence delirium occurred, pain scores stayed low, and adverse events matched ordinary postoperative symptoms. The team offers the numbers to guide dose choice in future trials of melatonin for children.
Catalog record
| CREATOR | Anne Louise de Barros Garioud, Arash Afshari, Lau Romlund Halgreen, Kristian Østergaard Nielsen, Lars Peter Kloster Andersen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32225 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |