Management of Breakthrough Bleeding During Emicizumab Prophylaxis in Acquired Haemophilia A: Data From the GTH‐AHA‐EMI Study
Halet Türkantoz, Christiane Dobbelstein, Richard Greil, Christina Hart, Robert Klamroth, Paul Knöbl, Johannes Oldenburg, Christian Pfrepper, Ulrich Sachs, Inga M. Schimansky, Karolin Trautmann‐Grill, Andreas Tiede · 2026
Read Management of Breakthrough Bleeding During Emicizumab Prophylaxis in Acquired Haemophilia A: Data From the GTH‐AHA‐EMI Study by Halet Türkantoz, Christiane Dobbelstein, Richard Greil, Christina Hart, Robert Klamroth, Paul Knöbl, Johannes Oldenburg, Christian Pfrepper, Ulrich Sachs, Inga M. Schimansky, Karolin Trautmann‐Grill, Andreas Tiede (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13551118.txt.
Description
Halet Türkantoz, leading eleven colleagues, published a 2026 report on breakthrough bleeding in the GTH-AHA-EMI study of acquired haemophilia A, a rare disorder where antibodies attack clotting factor VIII. A preventive drug, emicizumab, reduced bleeding overall, yet 22 clinically relevant new bleeds occurred in 14 of 47 patients during twelve weeks of prophylaxis. The team pulled study records and surveyed investigators for details.
Nine bleeds counted as major, fifteen arose spontaneously, and twenty needed treatment, most often with recombinant factor VIIa. Eight patients went to hospital and nine needed intensive care or invasive procedures, though most bleeds resolved and permanent harm was reported in two patients. No clotting complications appeared, so the authors call treatment safe and usually effective.
Catalog record
| CREATOR | Halet Türkantoz, Christiane Dobbelstein, Richard Greil, Christina Hart, Robert Klamroth, Paul Knöbl, Johannes Oldenburg, Christian Pfrepper, Ulrich Sachs, Inga M. Schimansky, Karolin Trautmann‐Grill, Andreas Tiede |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43232 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |