Colorectal Polyp Occurrence Associated With the ZMIZ1‐AS1 rs704017 Variant and Hypertension Among Taiwan Biobank Participants
Bei‐Hao Shiu, Hsu‐Chih Huang, Oswald Ndi Nfor, Shu‐Yi Hsu, Yung‐Po Liaw · 2026
Read Colorectal Polyp Occurrence Associated With the ZMIZ1‐AS1 rs704017 Variant and Hypertension Among Taiwan Biobank Participants by Bei‐Hao Shiu, Hsu‐Chih Huang, Oswald Ndi Nfor, Shu‐Yi Hsu, Yung‐Po Liaw (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13550769.txt.
Description
Colorectal polyps can grow into colorectal cancer, so knowing who is likelier to have them helps target screening. Bei-Hao Shiu and co-authors studied nearly nine thousand adults in the Taiwan Biobank, linking their records to national health insurance data. They tested two suspects: high blood pressure, and a gene variant called rs704017 in a stretch of RNA named ZMIZ1-AS1. Statistical models weighed both factors together.
People carrying the AG or GG form of the variant had clearly higher odds of polyps than those with the AA form. High blood pressure alone showed no solid link. But the two factors interacted: the variant's association with polyps ran stronger in people with hypertension. The authors conclude that this gene variant raises polyp odds on its own, and that blood pressure may sharpen the effect, hinting at a gene and lifestyle interplay worth further study.
Catalog record
| CREATOR | Bei‐Hao Shiu, Hsu‐Chih Huang, Oswald Ndi Nfor, Shu‐Yi Hsu, Yung‐Po Liaw |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |