Bioinformatic analysis reveals the potential association of ESRP1 with the splicing of cytoskeleton-associated genes in doxorubicin-resistant MCF7 breast cancer cells
Jing Zhang, Libin Chen, Qingling Song, Li Xu, Yinghua Li, Wen Li, Jie Wang · 2026
Read Bioinformatic analysis reveals the potential association of ESRP1 with the splicing of cytoskeleton-associated genes in doxorubicin-resistant MCF7 breast cancer cells by Jing Zhang, Libin Chen, Qingling Song, Li Xu, Yinghua Li, Wen Li, Jie Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13550377.txt.
Description
Jing Zhang and colleagues link a splicing factor's disappearance to doxorubicin resistance in breast cancer cells, in a 2026 bioinformatic study. Alternative splicing, the remixing of gene messages, goes wrong in cancer and can help tumors resist drugs. The team compared resistant MCF7 cells with their drug-sensitive parents and catalogued the splicing changes. They hunted for splicing factors whose loss tracks with those changes. A large patient cohort helped them build the correlation network.
Resistant cells showed widespread splicing shifts and sharply reduced ESRP1, a splicing factor of epithelial cells. Sixty-one splicing events tied confidently to its levels. Four affected genes help organize the cell's skeleton, fitting a picture where splicing rewires cell shape for survival under drug pressure. With only two samples per group, the authors flag the work as hypothesis-grade and call for bigger validation.
Catalog record
| CREATOR | Jing Zhang, Libin Chen, Qingling Song, Li Xu, Yinghua Li, Wen Li, Jie Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53278 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |