Surfactant-driven quorum sensing of Pseudomonas aeruginosa in cystic fibrosis
Prathibha Selvamani, James John, Janaki Devi Kumar, Sangeetha Gopalakrishnan, Jagadish Chandra Kumar Mangu, Priyatharshini Thangaraj, Krupakar parthasarathy · 2026
Read Surfactant-driven quorum sensing of Pseudomonas aeruginosa in cystic fibrosis by Prathibha Selvamani, James John, Janaki Devi Kumar, Sangeetha Gopalakrishnan, Jagadish Chandra Kumar Mangu, Priyatharshini Thangaraj, Krupakar parthasarathy (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13550369.txt.
Description
Prathibha Selvamani and colleagues review how the lung's own slippery coating may coach a stubborn bacterium to attack, in a 2026 article on cystic fibrosis. In this genetic disease, thick mucus invites chronic Pseudomonas infection. The bacteria talk through quorum sensing, a density signal. That signal switches on toxins, biofilms, and drug tolerance. Long-running inflammation alters lung surfactant, above all its main fat, DPPC.
New evidence suggests the altered lipids are not just damage markers but signals. They may trip the bacteria's chat system early, locking in virulence and persistence. The review assembles this host and pathogen dialogue. It weighs a counter-move: drugs modeled on surfactant that jam bacterial chatter instead. Weakening bacteria without killing them could sidestep the resistance pressure that antibiotics create, the authors argue.
Catalog record
| CREATOR | Prathibha Selvamani, James John, Janaki Devi Kumar, Sangeetha Gopalakrishnan, Jagadish Chandra Kumar Mangu, Priyatharshini Thangaraj, Krupakar parthasarathy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53964 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |