Transcription factors remodel tumor immune microenvironment by impacting multiple immune cells
Bei Xue, Chengwu He, Ye Tian · 2026
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Description
Bei Xue, Chengwu He, and Ye Tian organize the master switches of gene activity, transcription factors, by how they reshape the immune neighborhood around tumors, in a 2026 review. These proteins drive cancer growth and also reprogram infiltrating immune cells toward helping or fighting the tumor. The authors propose sorting them into three families by mechanism.
Direct-acting factors work inside single immune cell types, governing killer T cell exhaustion, helper cell balance, macrophage flavor, and the behavior of natural killers, dendritic cells, and suppressor cells. Coordinating factors act as bridges that get different immune cells cooperating. Dual-role factors flip sides depending on their variant forms or chemical modifications. The review closes with emerging drugs that target these switches, aiming to thaw frozen immune environments and partner with checkpoint inhibitors.
Catalog record
| CREATOR | Bei Xue, Chengwu He, Ye Tian |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65753 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |