Metabolic risk stratification and psychotic symptoms in first-episode drug-naïve major depressive disorder: a principal component-based cross-sectional study
Miao Chen, Xiaofang Shang, Xiao-E Lang, Junjun Liu, Xiangyang Zhang · 2026
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Description
Miao Chen and four co-authors probe the tie between body metabolism and psychotic symptoms in untreated depression, in a 2026 study. The patients, 1,718 in all, were in a first episode and had never taken medication.
Blood sugar, lipids, and body mass were compressed into two components. The first, mixing cholesterol and glucose, tracked most closely with psychotic symptoms. Yet path analysis found no direct link: depression and anxiety severity carried the statistical weight between them. Still, patients sorted into three metabolic risk bands showed a steep gradient, from under 1 percent with psychotic symptoms in the low band to about 32 percent in the high. Adjusted models kept metabolism as an independent signal.
Catalog record
| CREATOR | Miao Chen, Xiaofang Shang, Xiao-E Lang, Junjun Liu, Xiangyang Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |