ED95 determination of continuous norepinephrine infusion for preventing spinal anesthesia-induced hypotension in obese parturients during cesarean delivery
Rui Ran, Limeng Liu, Wenqian Li, Jing Li, Xiaofeng Lei, Jin Yu · 2026
Read ED95 determination of continuous norepinephrine infusion for preventing spinal anesthesia-induced hypotension in obese parturients during cesarean delivery by Rui Ran, Limeng Liu, Wenqian Li, Jing Li, Xiaofeng Lei, Jin Yu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13550186.txt.
Description
Rui Ran and co-authors measured how much blood-pressure drug obese women need during cesarean delivery, in a study published in 2026. Spinal anesthesia often drops blood pressure in childbirth, and norepinephrine infusions prevent that fall. The right preventive dose for obese patients was unknown. Eighty women having planned cesareans were split by body mass index into obese and non-obese groups. Doses were adjusted patient by patient using a biased-coin scheme that homes in on the effective level.
The dose effective in ninety-five percent of cases was about 0.066 micrograms per kilogram per minute for obese women. The non-obese group needed only about 0.045 on the same scale. Mother and baby outcomes did not differ between groups. The authors conclude that preventive dosing should be set by body size, not one-size-fits-all. Their numbers give anesthetists a concrete starting point for obese patients.
Catalog record
| CREATOR | Rui Ran, Limeng Liu, Wenqian Li, Jing Li, Xiaofeng Lei, Jin Yu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |