Multi-omics analysis reveals Protein Kinase A-associated regulatory remodeling during adaptation of Trichoderma reesei to lignocellulosic substrate
Hermano Zenaide-Neto, Wellington Ramos Pedersoli, David Batista Maués, Lucas Matheus Soares Pereira, Iasmin Cartaxo Taveira, Thiago de Andrade Simon, Andrei S Steindorff, Vitor Marcel Faça, Renato Graciano de Paula, Roberto N Silva · 2026
Read Multi-omics analysis reveals Protein Kinase A-associated regulatory remodeling during adaptation of Trichoderma reesei to lignocellulosic substrate by Hermano Zenaide-Neto, Wellington Ramos Pedersoli, David Batista Maués, Lucas Matheus Soares Pereira, Iasmin Cartaxo Taveira, Thiago de Andrade Simon, Andrei S Steindorff, Vitor Marcel Faça, Renato Graciano de Paula, Roberto N Silva (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13550043.txt.
Description
Hermano Zenaide-Neto and nine co-authors map how a protein kinase A pathway reshapes a fungus used to make industrial enzymes. Trichoderma reesei is a major source of enzymes that break down plant biomass. Nutrient sensing through the cyclic AMP and kinase A pathway guides its response to complex carbon sources such as sugarcane bagasse.
The team combines transcript, protein, and phosphorylation data for a normal strain and a strain lacking the kinase gene, grown on glucose or bagasse. Deletion alters growth traits and lowers output of some biomass degrading enzymes. Gene and protein changes hit enzyme sets, transporters, stress proteins, and regulators in a condition dependent way. Docking tests nominate candidate kinase targets for future validation work.
Catalog record
| CREATOR | Hermano Zenaide-Neto, Wellington Ramos Pedersoli, David Batista Maués, Lucas Matheus Soares Pereira, Iasmin Cartaxo Taveira, Thiago de Andrade Simon, Andrei S Steindorff, Vitor Marcel Faça, Renato Graciano de Paula, Roberto N Silva |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |