Protease-activated receptor 1 in diabetes and its chronic complications: signaling mechanisms and emerging therapeutic advances
Yanrui Wei, Bing Wang, Qiuyue Wang · 2026
Read Protease-activated receptor 1 in diabetes and its chronic complications: signaling mechanisms and emerging therapeutic advances by Yanrui Wei, Bing Wang, Qiuyue Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13549840.txt.
Description
Yanrui Wei, Bing Wang, and Qiuyue Wang review a receptor that sits at the crossroads of clotting and diabetes damage, in a 2026 paper. The receptor, PAR1, is switched on when enzymes cut it, and different cutting enzymes trigger different signal paths. Those paths feed into inflammation, scarring, blood vessel growth, and cell death. Diabetes harms the kidneys, eyes, nerves, and heart over years, and the review asks how much of that harm runs through this one receptor.
The authors trace its roles in insulin resistance in vessel walls, inflammation in fat tissue, and failing brown fat. They also survey new drug ideas aimed at the receptor. A single switch touching so many complications is an attractive target, if its clotting duties can be spared.
Catalog record
| CREATOR | Yanrui Wei, Bing Wang, Qiuyue Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |