Inflammatory-hemodynamic interplay in severe intracranial stenosis: hs-CRP, vertebral artery flow, and posterior circulation infarction
Xiaofeng Yuan, Yan Zhang, Wenjing Ma, Yakun Ren, Jun Shao · 2026
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Description
Five authors study how inflammation and blood flow jointly shape stroke risk in this 2026 paper. Their patients have severe narrowing of a vertebral artery inside the skull, and the outcome of interest is infarction in the back part of the brain.
The study followed 253 patients, of whom 96 had such an infarction. Higher levels of hs-CRP, a blood marker of inflammation, came with higher odds of infarction, with the link flattening at high levels. Network analysis put the marker at the center of the biomarker web. Early mediation results suggest artery flow partly carries the link. The pair of factors may act together, not just side by side.
Catalog record
| CREATOR | Xiaofeng Yuan, Yan Zhang, Wenjing Ma, Yakun Ren, Jun Shao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |