Causal associations of gastroesophageal reflux disease with sepsis and sepsis mortality within 28 days
Yangyang Tong, Jie Liu · 2026
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Description
Yangyang Tong and Jie Liu test whether reflux disease helps cause sepsis, a life-threatening response to infection. Earlier studies had linked gastroesophageal reflux disease with sepsis, but a link alone cannot show cause. The pair turn to Mendelian randomization, which uses genetic variants as a natural experiment.
Their 2026 study runs the test in both directions with several methods, plus checks for bias and outliers. Forward results suggest reflux raises the risk of sepsis and of death within twenty-eight days of sepsis. The reverse test found no clear effect of sepsis on reflux, though one result hinted the other way. The authors treat the main findings as robust across their checks.
Catalog record
| CREATOR | Yangyang Tong, Jie Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |