Targeted phagocytosis of TNF-α by CAR macrophages restores immune homeostasis in arthritis
Mei-Qi Wang, Jie Zhu, Chun-Yu Liu, Xiao-Lin Yu, Ya-Ru Huang, Lei Zhang, Shi-Yu Liang, Lixia Zhang, Hao-Tian Wang, Hongbo Cheng, Jia-Qian Chai, Xi-Xiu Xie, Rui-Tian Liu · 2026
Read Targeted phagocytosis of TNF-α by CAR macrophages restores immune homeostasis in arthritis by Mei-Qi Wang, Jie Zhu, Chun-Yu Liu, Xiao-Lin Yu, Ya-Ru Huang, Lei Zhang, Shi-Yu Liang, Lixia Zhang, Hao-Tian Wang, Hongbo Cheng, Jia-Qian Chai, Xi-Xiu Xie, Rui-Tian Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13549430.txt.
Description
Mei-Qi Wang and others engineered immune cells against arthritis inflammation in two thousand twenty-six. Rheumatoid joints fail to clear a key inflammatory signal. The body's own clearing cells are weakened in the disease. The team built receptor-armed macrophages in the lab. Their new catcher grabs that signal directly. How well they ate and broke down the signal was then tested.
Built cells ate up the signal far better than normal. Internal motion gear switched on strongly. Harmful output fell, and cell identity shifted for the better. Several signal pathways calmed as a result. Patient joint fluid tested the cells in a real-world way. Mouse tests set them against a standard drug. Cell therapy may restore joint immune balance.
Catalog record
| CREATOR | Mei-Qi Wang, Jie Zhu, Chun-Yu Liu, Xiao-Lin Yu, Ya-Ru Huang, Lei Zhang, Shi-Yu Liang, Lixia Zhang, Hao-Tian Wang, Hongbo Cheng, Jia-Qian Chai, Xi-Xiu Xie, Rui-Tian Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |