S100A8/A9 in Kidney Diseases: Mechanisms, Spatiotemporal Regulation, Biomarker Potential, and Therapeutic Implications
Meng-ge Zhu, Meng-dan Lu, Jia-wei Cao, Yue-wen Tang, Feng Wan · 2026
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Description
Meng-ge Zhu and co-authors review a swelling protein called S100A8 and S100A9 in kidney diseases, in work from twenty twenty-six. The protein pair drives immune activity and marks inflammation. Its role shifts with disease stage and tissue context, which past reviews missed.
Early in injury, the pair fans inflammation, hurts tubule cells, and aids scar build up. Later, it may help calm swelling and repair tissue. Levels in blood, urine, feces, and cell parcels could aid diagnosis and outlook checks. Blocking the pair protected kidneys in animal models. The authors propose a time and place frame for its action. Firm clinic trials are still lacking.
Catalog record
| CREATOR | Meng-ge Zhu, Meng-dan Lu, Jia-wei Cao, Yue-wen Tang, Feng Wan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |