Celecoxib Ameliorates Chronic Restraint Stress-Induced Depression-Like Behavior in Sprague-Dawley Rats
Yian Ling, Jing Li, Wanbin Liu, Yejun Gao, Lijuan Nie, Cuizhen Zhu, Qingrong Xia · 2026
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Description
Yian Ling and co-authors test a pain drug as an aid against stress-driven depression in rats, in a 2026 study. Long stress is tied to low mood, a strained stress-hormone axis, and inflammation. Celecoxib, a targeted anti-inflammatory painkiller, has been floated as an add-on for depression, but its behavior in a pure stress model needed closer work.
Male rats were split into four groups: calm controls, stressed rats, stressed rats given celecoxib, and stressed rats given a standard antidepressant. Stress meant four hours of restraint daily for six weeks, with drugs given in the last two. Behavior tests and body measures then compared the groups. The setup shows whether calming inflammation alone can lift stress-bred low mood.
Catalog record
| CREATOR | Yian Ling, Jing Li, Wanbin Liu, Yejun Gao, Lijuan Nie, Cuizhen Zhu, Qingrong Xia |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |