Association of CD16hiCD62Llo Neutrophils with Disease Severity and Impact of SYK Inhibition in Sepsis
Xianglan Yao, Heather L Teague, Lauren E Knabe, Raquel Santana da Cruz, Trenton Williams, Merte Lemma Woldehanna, Ernest Evans, Amir Hobson, Jared D Wilkinson, Cumhur Yusuf Demirkale, Steven D Nathan, Christopher King, Jeffrey R Strich · 2026
Read Association of CD16hiCD62Llo Neutrophils with Disease Severity and Impact of SYK Inhibition in Sepsis by Xianglan Yao, Heather L Teague, Lauren E Knabe, Raquel Santana da Cruz, Trenton Williams, Merte Lemma Woldehanna, Ernest Evans, Amir Hobson, Jared D Wilkinson, Cumhur Yusuf Demirkale, Steven D Nathan, Christopher King, Jeffrey R Strich (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13549185.txt.
Description
Xianglan Yao and co-authors study a neutrophil subset in sepsis in a 2026 paper. Sepsis, the body runaway response to infection, still lacks good markers and host-directed drugs. Blood tests on thirty-five patients and healthy controls flagged one white cell subset that rose with illness severity.
The subset tracked with intensive care need, blood pressure drugs, and death. It carried more of an enzyme called SYK than the same subset in healthy donors. In lab tests, a bacterial toxin grew the subset, and a SYK blocker stopped that shift. Readers get a candidate marker and drug target, with causal proof still to come.
Catalog record
| CREATOR | Xianglan Yao, Heather L Teague, Lauren E Knabe, Raquel Santana da Cruz, Trenton Williams, Merte Lemma Woldehanna, Ernest Evans, Amir Hobson, Jared D Wilkinson, Cumhur Yusuf Demirkale, Steven D Nathan, Christopher King, Jeffrey R Strich |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |