OLR1 as a Key Inflammatory Regulator Associated with Poor Response to Neoadjuvant Immunochemotherapy in Resectable Lung Cancer
Xinxin Chen, Siang Zhang, Xuefeng Ai, Yongfei Fan, Wenjie Chen · 2026
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Description
Xinxin Chen and four co-authors searched for why some lung cancers barely respond to chemotherapy combined with immunotherapy given before surgery. Using gene data from patient tumors, they sorted cancers into four groups by their inflammation patterns, which differed in survival. Single-cell and spatial mapping then compared strong responders with poor ones.
Poor responders' tumors burned hotter with inflammation. Certain neutrophil groups stood out, clustered in low-oxygen zones and tied to immune escape and new blood vessel growth. A gene called OLR1 sat at the center of this pattern, linking inflammation, immune suppression, and vessel growth. Cells carrying it behaved consistently across the analyses. The authors propose OLR1 as a marker of likely poor response and a possible target for improving treatment.
Catalog record
| CREATOR | Xinxin Chen, Siang Zhang, Xuefeng Ai, Yongfei Fan, Wenjie Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 98 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |