Data-driven modelling of tau pathology reveals distinct progressive supranuclear palsy subtypes
Patrick W Cullinane, Jacy Bezerra Parmera, Hemanth Nelvagal, Toby Curless, Leckhna Paras Chajed, Sarah Wrigley, Walter Sifontes Valladares, Maggie Burrows, Kirsten Ebanks, Lesley Wu, Lawrence P Binding, Jaime Anton, Tamas Revesz, Raquel Real, David P Vaughan, Edwin Jabbari, Huw R Morris, Sebastian B · 2026
Read Data-driven modelling of tau pathology reveals distinct progressive supranuclear palsy subtypes by Patrick W Cullinane, Jacy Bezerra Parmera, Hemanth Nelvagal, Toby Curless, Leckhna Paras Chajed, Sarah Wrigley, Walter Sifontes Valladares, Maggie Burrows, Kirsten Ebanks, Lesley Wu, Lawrence P Binding, Jaime Anton, Tamas Revesz, Raquel Real, David P Vaughan, Edwin Jabbari, Huw R Morris, Sebastian B (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13548875.txt.
Description
Patrick Cullinane and a large team of co-authors present a 2026 research paper on progressive supranuclear palsy, a brain disease marked by clumps of a protein called tau. The team studied 241 patients whose diagnosis was confirmed after death, drawn from a London brain bank. They wanted to know whether the disease follows distinct patterns as tau spreads through the brain.
The researchers measured tau in many brain regions using stained tissue scans and a computer method that sorts patients into subtypes and stages. They also recorded symptoms, genes, and survival times. Their modelling found distinct subtypes of the disease, which helps explain why patients differ so much in symptoms and speed of decline.
Catalog record
| CREATOR | Patrick W Cullinane, Jacy Bezerra Parmera, Hemanth Nelvagal, Toby Curless, Leckhna Paras Chajed, Sarah Wrigley, Walter Sifontes Valladares, Maggie Burrows, Kirsten Ebanks, Lesley Wu, Lawrence P Binding, Jaime Anton, Tamas Revesz, Raquel Real, David P Vaughan, Edwin Jabbari, Huw R Morris, Sebastian B |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |