Targeted proteomics reveal histiocytosis‐associated neurodegeneration signatures
Egle Kvedaraite, Magda Lourda, Johannes Bastiaan Munting, Matthias Papo, Martin Jädersten, Yoko Shioda, Kenichi Sakamoto, Daniel Martín Muñoz, Panagiotis Andriopoulos, Francesco Pegoraro, Evaldas Laurencikas, Ingrid Kühnle, Joakim Wille, Leonie Naeije, Helena Olkinuora, Indranil Sinha, Daniel W Hage · 2026
Read Targeted proteomics reveal histiocytosis‐associated neurodegeneration signatures by Egle Kvedaraite, Magda Lourda, Johannes Bastiaan Munting, Matthias Papo, Martin Jädersten, Yoko Shioda, Kenichi Sakamoto, Daniel Martín Muñoz, Panagiotis Andriopoulos, Francesco Pegoraro, Evaldas Laurencikas, Ingrid Kühnle, Joakim Wille, Leonie Naeije, Helena Olkinuora, Indranil Sinha, Daniel W Hage (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13548782.txt.
Description
Egle Kvedaraite and a large team of co-authors search for reliable markers of brain degeneration in Langerhans cell histiocytosis, a rare immune disorder. This complication is severe, but its biology and markers are poorly known. The team used targeted protein tests on spinal fluid and blood from patients with and without the brain complication, alongside control groups.
Spinal fluid from affected patients carried a distinct pattern: decoy receptors, signs of macrophage activation, and proteins tied to cell killing and immune control. One marker, IL-1RT2, picked out the brain complication more sharply than the standard nerve-damage marker and tracked changes over time. Blood tests echoed the spinal pattern and separated patients from controls in groups from France and Japan as well. The authors propose IL-1RT2 as a candidate marker for diagnosis and monitoring of this complication.
Catalog record
| CREATOR | Egle Kvedaraite, Magda Lourda, Johannes Bastiaan Munting, Matthias Papo, Martin Jädersten, Yoko Shioda, Kenichi Sakamoto, Daniel Martín Muñoz, Panagiotis Andriopoulos, Francesco Pegoraro, Evaldas Laurencikas, Ingrid Kühnle, Joakim Wille, Leonie Naeije, Helena Olkinuora, Indranil Sinha, Daniel W Hage |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |