HMGB1 promotes radiotherapy resistance in human cervical cancer HeLa cells through regulating the AMPK/mTOR signaling
Youyou Xie, Changhui Yu, Miao Wang, Yaqin Lin, Biyun Wang · 2026
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Description
Youyou Xie and colleagues create radiation-resistant cervical cancer cells in the laboratory to learn how a nuclear protein helps tumors shrug off radiotherapy, in a 2026 study. Resistant disease is a major reason treatment fails. Repeated X-ray doses bred a resistant HeLa cell line, which turned out to carry far more HMGB1, a protein spilled during radiation, than its parent cells.
Silencing that protein restored radiation sensitivity and switched on the energy sensor AMPK, while blocking AMPK brought the resistant behavior back. A growth pathway downstream, mTOR, linked the two effects. Patient tissue echoed the pattern: tumors from people whose cancers resisted radiation showed high HMGB1 and low activated AMPK. The authors nominate the HMGB1 to AMPK axis as a drug target, while noting patient validation is still thin.
Catalog record
| CREATOR | Youyou Xie, Changhui Yu, Miao Wang, Yaqin Lin, Biyun Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52059 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |