Elution kinetics and antimicrobial efficacy of high-dose gram-negative antibiotic-loaded acrylic cement: an in vitro and in vivo study
Jian Wei, Zhiyang He, Jiayue Xie, Kai Tong · 2026
Read Elution kinetics and antimicrobial efficacy of high-dose gram-negative antibiotic-loaded acrylic cement: an in vitro and in vivo study by Jian Wei, Zhiyang He, Jiayue Xie, Kai Tong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13548531.txt.
Description
Jian Wei and colleagues compare six antibiotics mixed into acrylic bone cement for fighting Gram-negative infections around joint implants, in a 2026 laboratory and animal study. Surgeons use such cement to hold implants and deliver medicine locally, yet no shared guidance exists on which drug to choose. Each antibiotic was loaded at high dose into cement samples for release, strength, and bacteria-killing tests over twenty-eight days.
Adding any drug weakened the cement somewhat, though most mixes stayed above the accepted strength threshold. Tobramycin released the most drug overall, while meropenem killed bacteria most strongly in the dish. Meropenem cement then went into rats with infected joint implants, where treated animals carried far fewer bacteria in surrounding tissues than controls. The authors frame the results as a starting point for cement selection in Gram-negative infections.
Catalog record
| CREATOR | Jian Wei, Zhiyang He, Jiayue Xie, Kai Tong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59287 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |